Curriculum Vitae

 

 

Name:         Mark A. Estelle                                                                                                                                                                                                                                                            01/05

 

Birthdate: December 30, 1955

 

Phone: 812-856-1216

 

Fax: 812-856-6082

 

email: maestell@indiana.edu

 

Education:

 

                        University of Alberta, Edmonton, Alberta, Canada, 1974‑1978

                        Bsc. with honors in Genetics.

 

                        University of Alberta, Edmonton, Alberta, Canada, 1979‑1983

                        Ph.D. in genetics

                        Thesis title: "The analysis of a dopa decarboxylase activity

                        variant in Drosophila melanogaster."

 

Awards:

 

                        Natural Sciences and Engineering Research Council of Canada

                        Postgraduate Scholarship. 1979‑1983.

 

                        Alberta Heritage Trust Fund Postgraduate Research Award

                        1981‑1983.

 

                        Department of Biology Teaching Award. 1989

 

                        Senior Class Award for Teaching Excellence. 1995

 

                        Elected Fellow AAAS, 2002

 

Academic Appointments:

 

                        Research Associate, MSU‑DOE Plant Research Laboratory,

                        Supervisor: Dr. Chris Somerville. September 1983 to October

                        1986

 

                        Assistant Professor, Department of Biology, Indiana

                        University. November 1986 to June 1993.

 

                        Associate Professor, Department of Biology, Indiana University                                                       July 1993 to June 1999

 

                        Fellow, Indiana Institute for Molecular and Cellular Biology. November                                           1986 to June 1999.

 

D.J. Sibley Professor of Molecular Genetics, Section of Molecular, Cellular and Developmental Biology, 1999 to 2002

 

Professor and Carlos Miller Chair of Plant Developmental Biology, 2002 - present

 

                       


Research Articles

 

1.      Kraminsky, G.P., W.C. Clark, M.A. Estelle, R.D. Gietz, B.A. Sage, J.D. O'Connor and R.B. Hodgetts. 1980. Induction of translatable mRNA for dopa decarboxylase in Drosophila: an early response to ecdysone. Proc. Natl. Acad. Sci. USA 77:4175-4179

 

2.      Estelle, M.A. and R.B. Hodgetts. 1984. Genetic elements near the structural gene modulate the level of dopa decarboxylase during Drosophila development. Mol. Gen. Genet. 195:434-441.

 

3.      Estelle, M.A. and R.B. Hodgetts. 1984. Insertion plymorphisms may cause stage specific variation in mRNA levels for dopa decarboxylase in Drosophila. Mol. Gen. Genet. 195:442-451

 

4.      Estelle, M.A., J. Hanks, L. McIntosh, C.R. Somerville. 1985. Site-specific mutagenesis of ribulose-1,5-bisphosphate carboxylase/oxygenase. J. Biol. Chem. 260:9523-9526.

 

5.      Estelle, M.A. and Somerville, C.R. (1987) Auxin resistant mutants of Arabidopsis  with an altered morphology. Mol. Gen. Genet. 206, 200‑206

 

6.      Bleecker, A.B., Estelle, M.A., Somerville, C.R. and Kende, H. (1988) Insensitivity to ethylene conferred by a dominant mutation in Arabidopsis thaliana Science 241, 1086‑1089

 

7.      Wilson, A.K., Pickett, F.B., Turner, J.C. and Estelle, M. (1990) A dominant mutation in Arabidopsis confers resistance to auxin, ethylene and abscisic acid. Mol. Gen. Genet. 222, 377‑383

 

8.      Pickett, F.B.  Wilson, A.K. and Estelle, M. (1990) The aux1 mutation of Arabidopsis confers both auxin and ethylene resistance. Plant Physiol.  94:1462‑1466.

 

9.      Lincoln, C. and Estelle, M. (1990) The axr1 mutation of Arabidopsis  is Expressed in Both Roots and Shoots. Jour. Iowa Acad. Sci. 98:68‑71

 

10.  Lincoln, C., Britton, J.H. and Estelle, M. (1990) Growth and Development of the axr1 Mutants of Arabidopsis. Plant Cell 2:1071‑1080.

 

11.  Lincoln, C., Turner, J., and Estelle, M. (1992) Hormone‑Resistant Mutants of Arabidopsis Have an Attenuated Response to Agrobacterium Strains. Plant Physiol. 98:979‑983

 

12.  Timpte, C., Wilson, A.K., and Estelle, M. (1992) Effects of the axr2 Mutation of Arabidopsis on Cell Shape in Hypocotyl and Inflorescence. Planta 188:271‑278.

 

13.  Leyser, H.M.O., Lincoln, C., Timpte, C. Lammer, D., Turner, J., and Estelle, M. (1993) The auxin‑resistance gene AXR1 of Arabidopsis encodes a protein related to ubiquitin‑activating enzyme E1. Nature  364:161-164.

 

14.  Evans, M.L., Ishikawa, H. and M.A. Estelle. (1994) Responses of Arabidopsis roots to auxin studied with high temporal resolution: Comparison of wild type and auxin response mutants. Planta  194:215-222

 

15.  Timpte, C., Wilson, A., and M. Estelle (1994)  The axr2‑1 mutation of Arabidopsis thaliana is a gain‑of‑function mutation that disrupts an early step in auxin response. Genetics 138:1239-1249

 

16.  Hobbie, L., and M. Estelle (1995) The axr4 auxin-resistant mutants of Arabidopsis thaliana define a gene important for root gravitropism and lateral root initiation. Plant J. 7:211-220

 

17.  Romano, P.C., Robson, P.R.H., Smith H., Estelle, M., and H. Klee (1995) Transgene-mediated auxin overproduction in Arabidopsis: hypocotyl elongation phenotype and interactions with the hy6-1 hypocotyl elongation and axr1 auxin-resistant mutants. Plant  Mol. Biol.  27:1071-1083.

 

18.  Timpte, C, Lincoln, C, Pickett, F.B., Turner, J., and M. Estelle (1995) The AXR1 and AUX1 genes of Arabidopsis  function in separate auxin-response pathways. Plant J. 8:561-569

 

19.  Leyser, H.M.O. Pickett, F.B., Dharmaseri, S., and Mark Estelle (1996) Mutations in the AXR3 gene of Arabidopsis result in altered auxin response including ectopic expression of the SAUR-AC1 promoter. Plant J.  10:403-414.

 

20.  Cernac, A. Lincoln, C., Lammer, D., and M. Estelle (1997) The SAR1  gene of Arabidopsis  acts downstream of theAXR1  gene in auxin response. Development  124:1583-1591

 

21.  Ruegger, M., Dewey, E., Hobbie, L., Brown, D., Bernasconi, P., Turner, J., Muday, G., and M. Estelle. (1997) Reduced NPA-binding in the tir3 mutant of Arabidopsis is Associated with a reduction in polar auxin transport and diverse morphological defects. Plant Cell,  9:745-757

 

22.  Sponsel, V.M., Schmidt, F.W., Farris, S.G., Nakayama, M., Kohlstruk, S. and M. Estelle. (1997) Characterization of new Gibberellin-Responsive Semidwarf Mutants of Arabidopsis. Plant Physiol. 115: 1009-1020.

 

23.  Jensen, P.J., Hangarter, R.P., and M. Estelle (1998) Auxin transport is required for hypocotyl elongation in light-grown but not dark-grown Arabidopsis. Plant Physiol. 116:455-462

 

24.  Ruegger, M. Dewey, E., Gray, W.M., Hobbie, L., Turner, J., and M. Estelle. (1998) The TIR1 Protein of Arabidopsis Functions in Auxin Response and is Related to Human SKP2 and Yeast Grr1p. Genes and Development. 12:198-207.

 

25.  Rouse, D., Mackay, P., Stirnberg, P., Estelle, M., and O. Leyser. (1998) Changes in auxin response from mutations in an AUX/IAA gene. Science 279:1371

 

26.  Lammer, D., Mathias, N., Laplaza, J.M., Jiang, W., Liu, Y., Callis, J., Goebl, M., and M. Estelle. (1998) Modification of Cdc53p by the ubiquitin-related protein Rub1p affects function of SCFCdc4 in yeast Genes and Development. 12:914-926.

 

27.  Gray, W.M.,Anders Ostin, Charley P. Romano, Goran Sandberg and M. Estelle. (1998) High Temperature Promotes Auxin-Mediated Hypocotyl Elongation in Arabidopsis. Proc. Natl. Acad. Sci. 95:7197-7202

 

28.  J.C. del Pozo, C. Timpte, S. Tan, J. Callis, and M. Estelle. (1998) The ubiquitin-related protein RUB1 and auxin response in Arabidopsis. Science  280: 1760-1763.

 

29.  Estelle, M. (1998) Polar Auxin Transport: New Support for an Old Model. Plant Cell 10:1775-1778.

 

30.  Pitts, R.J., Cernac, A., and M. Estelle. (1998). Auxin and ethylene promote root hair elongation in Arabidopsis. Plant J   16:553-560.

 

31.  Gray, W.M., del Pozo, J.C., Walker, L., Hobbie, L., Risseeuw, E., Banks, T., Crosby, W.L., Yang, M., Ma, H., and M. Estelle. (1999) Identification of an SCF  ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.  Genes and Dev.13:1678-1691.

 

32.  J.C. del Pozo and M. Estelle. (1999). The Arabidopsis Cullin AtCUL1 is Modified by the Ubiquitin-Related Protein RUB1. Proc. Natl. Acad. Sci. 96:15342-15347.

 

33.  Hobbie, L., McGovern, M., Hurwitz, L.R., Pierro, A., Liu, N.Y., Bandyopadhyay, A., and M. Estelle. (2000) The axr6 mutants of Arabidopsis define a gene involved in auxin response and early develoment. Development .127:23-32

 

34.  Nagpal, P., Walker, L., Young, J., Sonawala, A., Timpte, C., Estelle, M. and J. W. Reed. (2000) AXR2 encodes a member of the Aux/IAA protein family. Plant Physiology.123:563-573.

 

35.  Schwechheimer, C,, Serino, G, Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M, Estelle, M., and X-W. Deng. (2001). Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin response. Science 292:1379-1382.

 

36.  Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K.C., Putteril, J., Palme, K., Estelle, M., and J. Chory. (2001) BIG, a calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Dev.,15: 1985-1997.

 

37.  Gray, W.M., Kepinski, S., Rouse, D., Leyser, O., and M. Estelle., (2001) Auxin Regulates SCFTIR1-Dependent Degradation of the Aux/IAA Proteins. Nature 414:271-276

 

38.  del Pozo, J.C., Dharmasiri, S., Hellmann, H., Walker, L., Gray, W.M. and M. Estelle., (2002) AXR1-ECR1-Dependent Conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is Required for Auxin Response. Plant Cell 14: 421-433.

 

39.  W-H Shen, Parmentier, Y.., Hellmann, H.,  Lechner, E., Dong, A., Masson, J., Granier, F., Lepiniec, L., Estelle, M., and Pascal Genschik. (2002) Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis. MBC, 13:1916-28..

 

40.  Gray, W. M., Hellmann, H., Dharmasiri, S., and M. Estelle (2002). Role of the Arabidopsis RING-H2 finger protein RBX1 in RUB modification and SCF function. Plant Cell. 14:2137-2144

 

41.  Dharmasiri, S., Dharmasiri, N., Hellmann, H., and M. Estelle. 2003 The RUB/Nedd8 conjugation pathway is required for auxin response and early development in Arabidopsis. EMBO J 22:1762-70.

 

42.  Risseeuw, E.P., Daskalchuk, T.E., Banks, T.W., Liu, E., Cotelesage, J., Hellmann, H., Estelle, M., Somers, D.E., and Crosby, W.L. 2003 Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis. Plant J. 34:753-67.

 

43.  Hellmann, H., Hobbie, L., Chapman, A., Dharmasiri, S., Dharmasiri, N., del Pozo, C., Reinhardt, D., and M. Estelle 2003. AXR6 encodes CUL1 implicating SCF ubiquitin ligases in auxin regulation of embryogenesis. EMBO J. 22:3314-3325.

 

44.  Dharmasiri, N., Dharmasiri, S., Jones, A.M., and M. Estelle. 2003, Auxin Action in a Cell-Free System. Current Biology, 13(16):1418-22.

 

45.   Yang, X., Lee, S., So, J-H., Dharmasiri, S. Dharmasiri, N. Lei, G., Jensen, C., Hangarter, R., Hobbie, L., and Estelle M. 2004. The IAA1 protein is encoded by AXR5 and is a substrate of SCFTIR1. Plant J. 772-782.

 

46.  Weber, H., Bernhardt, A., Dieterle, M., Hano, P., Mutlu, A.,Estelle, M., Genschik, P.,  Hellmann, H. 2004. Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH Protein Family. Plant Physiol. In Press.

 

 

           

 

 

 

Invited Reviews and Book Chapters

 

1.      Estelle, M. A. and C.R. Somerville. 1986. The mutants of Arabidopsis. Trends in Genetics. 2:89-93.

 

2.      Finkelstein, R., Estelle, M., Martinez‑Zapater, J., and Somerville, C.R. (1988) Arabidopsis  as a tool for the identification of genes involved in plant development. In Plant  Gene Research vol V. D.P.S. Verma and R. Goldberg, eds. Springer‑Verlag, New York.

 

3.      Klee, H. and Estelle, M. (1991) Molecular Genetic Approaches to the Biology of Plant Hormones. Ann. Rev. Plant Physiol. and Mol. Biol. 42:529‑551

 

4.      Estelle, M. 1992 The Plant Hormone Auxin: Insight In Sight. BioEssays 14:439‑444

 

5.      Hobbie, L. and M.A. Estelle (1994) Genetic approaches to auxin action. Plant Cell and Environment  17:525-540

 

6.      Estelle, M. and H. J. Klee (1994) Auxin and cytokinin in Arabidopsis . In Arabidopsis (ed. E. Meyerowitz and C. Somerville). Cold Spring Harbor Press, Cold Spring Harbor, NY. pages 555-578

 

7.      Hobbie, L., Timpte, C., and M. Estelle (1994) Molecular genetics of auxin and cytokinin. Plant Molecular Biology 26:1499-1519

 

8.      Estelle, M. (1996) Root Gravitropism: Auxin Ins and Outs. Current Biology. 6:1589-1591

 

9.      Gray, W. M. and M. Estelle. (1998) Biochemical Genetics of Plant Growth. Curr Opinion in Biotech. 9:196-201

 

10.  Estelle, M. (1999) Auxin perception and transduction. IN Biochemistry and Molecular Biology of Plant Hormones. eds. P. Hooykaas, M. Hall, and K. Libbenga. Elsevier. pp. 411-422

 

11.  Estelle, M. (1998) Two receptors better than one? Curr. Biol. 8:539-541.

 

12.  Walker, L., and M. Estelle. (1998) Molecular Mechanism of Auxin Action. Curr. Opinion in Plant Biol. 434-439.

 

13.  del Pozo, C. J., Estelle, M. (1999) Function of the ubiquitin-proteosome pathway in auxin response. Trends in Plant Sciences 4:107-112.

 

14.  Estelle, M. and J. Chory. (1999) Editorial Overview: signals and pathways - keeping track of what's going on. Current Opinion in Plant Biology. 2:349-351.  This issue was edited by Joanne Chory and Mark Estelle.

 

15.  del Pozo , J.C., and M. Estelle. (2000) F-box proteins and protein degradation: an emerging theme in cellular regulation. Plant Mol. Biol. 44:123-8.

 

16.  Gray, W.M. and M. Estelle (2000) Function of the ubiquitin-proteasome pathway in auxin response. Trends in Biochemical Sciences. 24: 133-138.

 

17.  Estelle, M (2001) Proteases and Cellular Regulation in Plants. Curr. Opinion in Plant Biol. 4:254-260

 

18.  Estelle, M (2001) Cytokinin  Receptor: Just another histidine kinase. Curr. Biol. 11:271-274.

 

19.  Estelle, M (2001) Plant hormone: Transporters on the move. Nature 413:374-375

 

20.  Dharmasiri, S., and M. Estelle (2002) The Role of Regulated Protein Degradation In Auxin Response. Plant Mol. Biol 49:401-409.

 

21.  Ward, S. and M. Estelle (2001) Auxin Signalling Involves Regulated Protein Degradation by the Ubiquitin-Proteasome Pathway. J. Plant Growth Regulators 20: 265-273.

 

22.  Hellmann, H, and M. Estelle (2002) Plant Development: Regulation by Protein Degradation. Science 297:793-797.

 

23.  Parry, G. and M. Estelle. (2004) Regulation of cullin based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Seminars in Cell and Developmental Biology. 15:221-229

 

24.  Dharmasiri, N. and M. Estelle. (2004) Auxin signaling and Regulated Protein Degradation. Trends in Plant Science. 9:302-308.

 

25.  Moon, J., Parry, G., and M. Estelle (2004) The Ubiquitin Proteasome Pathway and Plant Development. Plant Cell. 16:3181-3195.

 

26.  Mockaitis, K., and M. Estelle (2004) Integrating Transcriptional Controls for Plant Cell Expansion. Genome Biology 5:245.

 

 

Grants:

 

1986-87           NIH BRSG SO7 RR 07031, $10,000 (D)

1987-90           NSF DCB-8702448, $234,000

1989-93           NIH GM43644-01, $281,374 (D)

1990-93           NSF DCB-9004991, $180,000

1993-97           NSF IBN-9307134, $357,574

1993-96           NIH GM43644, $364,662 (D)

1996-2000       NSF IBN-9604398, $285,000

1997-2001       NIH GM43644, $572,104 (D)

1999-2001       DOE DE-FG03-99ER20327 $190,000

2000-2001       ARP $153,472

2000-2003              NSF PGR-0077769 $ 219,817. This is a project grant awarded to five institutions. UT Austin is the lead institution and I am the PI. Total size of the award is $1,336,086.

2001-2004              DOE DE-FG03-99ER20327, $351,000  (D + I)

2001-2005       NSF 0115870. This is a project grant awarded to four institutions and administered by Rick Vierstra at the University of Wisconsin. Total size of the award is $ 3,310,049. My budget is $651,000 (D + I)

2001-2005       NIH GM43644, $720.000 (D)

2004 –2007     DOE  DE-FG02-02ER15312

2005 – 2009    NIH, GM43644 Pending

 

 

 

 

Grants to Postdoctoral Fellows:

 

1990-93           NSF Postdoctoral Research Fellowship in Plant Biology to Dr. Lawrence Hobbie.

1991-93           NIH Postdoctoral Fellowship to Dr. Candace Timpte.

1991-94           AFRC Postdoctoral Fellowship to Dr. Ottoline Leyser.

1994-97           NIH Postdoctoral Fellowship to Dr. Loni Walker

1997-2000       NIH Postdoctoral Fellowship to Dr. William Gray

1997-1999       Spanish Postdoctoral Fellowship to Dr. Carlos del Pozo

2000-2002              German Postdoctoral Fellowship to Dr. Hanjo Hellmann